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Open Access Nano Express

Nitric oxide-releasing porous silicon nanoparticles

Morteza Hasanzadeh Kafshgari1, Alex Cavallaro1, Bahman Delalat1, Frances J Harding1, Steven JP McInnes1, Ermei Mäkilä2, Jarno Salonen2, Krasimir Vasilev1 and Nicolas H Voelcker1*

Author Affiliations

1 ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Mawson Institute, University of South Australia, GPO Box 2471 Adelaide, SA 5001, Australia

2 Department of Physics and Astronomy, University of Turku, Turku FI-20014, Finland

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Nanoscale Research Letters 2014, 9:333  doi:10.1186/1556-276X-9-333

Published: 4 July 2014

Abstract

In this study, the ability of porous silicon nanoparticles (PSi NPs) to entrap and deliver nitric oxide (NO) as an effective antibacterial agent is tested against different Gram-positive and Gram-negative bacteria. NO was entrapped inside PSi NPs functionalized by means of the thermal hydrocarbonization (THC) process. Subsequent reduction of nitrite in the presence of D-glucose led to the production of large NO payloads without reducing the biocompatibility of the PSi NPs with mammalian cells. The resulting PSi NPs demonstrated sustained release of NO and showed remarkable antibacterial efficiency and anti-biofilm-forming properties. These results will set the stage to develop antimicrobial nanoparticle formulations for applications in chronic wound treatment.

Keywords:
Porous silicon nanoparticles; Nitric oxide; Antibacterial