Open Access Nano Express

The synthesis and characterization of monodispersed chitosan-coated Fe3O4 nanoparticles via a facile one-step solvothermal process for adsorption of bovine serum albumin

Mao Shen1, Yujing Yu1, Guodong Fan2, Guang Chen1, Ying min Jin3, Wenyuan Tang1 and Wenping Jia1*

Author Affiliations

1 College of Pharmaceutical and Chemical Engineering, Taizhou University, Jiaojiang 318000, People's Republic of China

2 Key Laboratory of Auxiliary Chemistry and Technology for Chemical Industry, Ministry of Education, Shan xi University of Science and Technology, Xi'an 710021, People's Republic of China

3 College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, People's Republic of China

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Nanoscale Research Letters 2014, 9:296  doi:10.1186/1556-276X-9-296

Published: 11 June 2014


Preparation of magnetic nanoparticles coated with chitosan (CS-coated Fe3O4 NPs) in one step by the solvothermal method in the presence of different amounts of added chitosan is reported here. The magnetic property of the obtained magnetic composite nanoparticles was confirmed by X-ray diffraction (XRD) and magnetic measurements (VSM). Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) allowed the identification of spherical nanoparticles with about 150 nm in average diameter. Characterization of the products by Fourier transform infrared spectroscopy (FTIR) demonstrated that CS-coated Fe3O4 NPs were obtained. Chitosan content in the obtained nanocomposites was estimated by thermogravimetric analysis (TGA). The adsorption properties of the CS-coated Fe3O4 NPs for bovine serum albumin (BSA) were investigated under different concentrations of BSA. Compared with naked Fe3O4 nanoparticles, the CS-coated Fe3O4 NPs showed a higher BSA adsorption capacity (96.5 mg/g) and a fast adsorption rate (45 min) in aqueous solutions. This work demonstrates that the prepared magnetic nanoparticles have promising applications in enzyme and protein immobilization.

Magnetic nanoparticles; Chitosan; Solvothermal; BSA adsorption