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Ethylenediaminetetraacetic acid as capping ligands for highly water-dispersible iron oxide particles

Yunfeng Yi13, Ying Zhang2, Yixiao Wang3, Lihua Shen3, Mengmeng Jia3, Yu Huang3, Zhenqing Hou3* and Guohong Zhuang45*

Author Affiliations

1 The Affiliated Southeast Hospital of Xiamen University, Zhangzhou 363000, China

2 Department of Radiology, Taishan Medical University, Taishan, Shandong 271016, China

3 Research Center of Biomedical Engineering, Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, China

4 Organ Transplantation Institute, Medical College, Xiamen University, Xiamen 361005, China

5 Anti-Cancer Research Center, Medical College, Xiamen University, Xiamen 361005, China

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Nanoscale Research Letters 2014, 9:27  doi:10.1186/1556-276X-9-27

Published: 14 January 2014


Monodispersed magnetite (Fe3O4) particles were synthesized using a high-temperature hydrolysis reaction with the assistance of ethylenediaminetetraacetic acid (EDTA) as capping ligands. These particles were composed of small primary nanocrystals and their sizes could be tuned from about 400 to about 800 nm by simply changing the EDTA or precursor concentration. Surface-tethered EDTA made the particles highly water-dispersible. The as-prepared magnetite particles also showed superparamagnetic behavior at room temperature, and their magnetic properties were size dependent. In addition, the particles had a strong response to external magnetic field due to their high magnetization saturation values. These properties were very important for some potential biomedical applications, such as magnetic separation and magnetic-targeted substrate delivery.

Magnetite; Magnetic properties; Nanocrystalline materials