Open Access Nano Express

Tunable biphasic drug release from ethyl cellulose nanofibers fabricated using a modified coaxial electrospinning process

Chen Li1, Zhuan-Hua Wang1*, Deng-Guang Yu2* and Gareth R Williams3

Author Affiliations

1 Key Laboratory of Chemical Biology and Molecular Engineering, College of Life Science, Shanxi University, 92 Wucheng Road, Taiyuan 030006, China

2 School of Materials Science & Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China

3 Upalitocacy, 29-39 Brunswick Square, London WC1N 1AX, UK

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Nanoscale Research Letters 2014, 9:258  doi:10.1186/1556-276X-9-258

Published: 23 May 2014

Abstract

This manuscript reports a new type of drug-loaded core-shell nanofibers that provide tunable biphasic release of quercetin. The nanofibers were fabricated using a modified coaxial electrospinning process, in which a polyvinyl chloride (PVC)-coated concentric spinneret was employed. Poly (vinyl pyrrolidone) (PVP) and ethyl cellulose (EC) were used as the polymer matrices to form the shell and core parts of the nanofibers, respectively. Scanning and transmission electron microscopy demonstrated that the nanofibers had linear morphologies and core-shell structures. The quercetin was found to be present in the nanofibers in the amorphous physical status, on the basis of X-ray diffraction results. In vitro release profiles showed that the PVP shell very rapidly freed its drug cargo into the solution, while the EC core provided the succedent sustained release. Variation of the drug loading permitted the release profiles to be tuned.

Keywords:
Modified coaxial electrospinning; Core-shell nanofibers; Tunable biphasic release; PVC-coated spinneret; Ethyl cellulose