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Open Access Nano Review

A sight on the current nanoparticle-based gene delivery vectors

Solmaz Maleki Dizaj123, Samira Jafari123 and Ahmad Yari Khosroushahi45*

Author Affiliations

1 Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

2 Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran

3 Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

4 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

5 Department of Pharmacognosy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Daneshgah Street, P.O.Box 51664, 14766 Tabriz, Iran

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Nanoscale Research Letters 2014, 9:252  doi:10.1186/1556-276X-9-252

Published: 21 May 2014

Abstract

Nowadays, gene delivery for therapeutic objects is considered one of the most promising strategies to cure both the genetic and acquired diseases of human. The design of efficient gene delivery vectors possessing the high transfection efficiencies and low cytotoxicity is considered the major challenge for delivering a target gene to specific tissues or cells. On this base, the investigations on non-viral gene vectors with the ability to overcome physiological barriers are increasing. Among the non-viral vectors, nanoparticles showed remarkable properties regarding gene delivery such as the ability to target the specific tissue or cells, protect target gene against nuclease degradation, improve DNA stability, and increase the transformation efficiency or safety. This review attempts to represent a current nanoparticle based on its lipid, polymer, hybrid, and inorganic properties. Among them, hybrids, as efficient vectors, are utilized in gene delivery in terms of materials (synthetic or natural), design, and in vitro/in vivo transformation efficiency.

Keywords:
Gene delivery; Non-viral vectors; Nanoparticles; Inorganic vectors