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Open Access Nano Review

Dendrimers: synthesis, applications, and properties

Elham Abbasi1, Sedigheh Fekri Aval12, Abolfazl Akbarzadeh1*, Morteza Milani13, Hamid Tayefi Nasrabadi1*, Sang Woo Joo4*, Younes Hanifehpour4*, Kazem Nejati-Koshki12 and Roghiyeh Pashaei-Asl1

Author Affiliations

1 Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz 5154853431, Iran

2 Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz 5154853431, Iran

3 Department of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz 5154853431, Iran

4 School of Mechanical Engineering, Yeungnam University, Gyeongsan 712-749, South Korea

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Nanoscale Research Letters 2014, 9:247  doi:10.1186/1556-276X-9-247

Published: 21 May 2014

Abstract

Dendrimers are nano-sized, radially symmetric molecules with well-defined, homogeneous, and monodisperse structure that has a typically symmetric core, an inner shell, and an outer shell. Their three traditional macromolecular architectural classes are broadly recognized to generate rather polydisperse products of different molecular weights. A variety of dendrimers exist, and each has biological properties such as polyvalency, self-assembling, electrostatic interactions, chemical stability, low cytotoxicity, and solubility. These varied characteristics make dendrimers a good choice in the medical field, and this review covers their diverse applications.

Keywords:
Dendrimer; Pseudorotaxane; Nanoscale; PAMAM