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Open Access Nano Express

In vitro uptake of apoptotic body mimicking phosphatidylserine-quantum dot micelles by monocytic cell line

Andrei Maiseyeu1 and Vaishali Bagalkot12*

Author Affiliations

1 Division of Cardiovascular Medicine, Department of Medicine, University of Maryland, Baltimore, 20 Penn St., HSFII, S012D, Baltimore, MD 21201, USA

2 Department of Internal Medicine/Cardiology, University of Texas Health Science Center (UTHSC), 1881 East Road, South Campus Research Building 3, Center for Advanced Biomedical Imaging Research, 3SCR6.4610, Houston, TX 77054, USA

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Nanoscale Research Letters 2014, 9:176  doi:10.1186/1556-276X-9-176

Published: 11 April 2014

Abstract

A new quantum dot (QD) PEGylated micelle laced with phosphatidylserine (PS) for specific scavenger receptor-mediated uptake by macrophages is reported. The size and surface chemistry of PS-QD micelles were characterized by standard methods and the effects of their physicochemical properties on specific targeting and uptake were comprehensively studied in a monocytic cell line (J774A.1).

Keywords:
Phosphatidylserine; Micelles; Quantum dots; Macrophages