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Effect of nitrogen atomic percentage on N+-bombarded MWCNTs in cytocompatibility and hemocompatibility

Mengli Zhao1, Ye Cao1, Xiaoqi Liu1, Jianhua Deng1, Dejun Li1* and Hanqing Gu23

Author Affiliations

1 College of Physics and Materials Science, Tianjin Normal University, Tianjin 300387, China

2 Tianjin Institute of Urological Surgery, Tianjin Medical University, Tianjin 300070, China

3 School of Medicine, Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai 200011, China

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Nanoscale Research Letters 2014, 9:142  doi:10.1186/1556-276X-9-142

Published: 25 March 2014

Abstract

N+-bombarded multi-walled carbon nanotubes (N+-bombarded MWCNTs), with different nitrogen atomic percentages, were achieved by different N ion beam currents using ion beam-assisted deposition (IBAD) on MWCNTs synthesized by chemical vapor deposition (CVD). Characterizations of N+-bombarded MWCNTs were evaluated by X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), Raman spectroscopy, and contact angle. For comparison, the in vitro cytocompatibility of the N+-bombarded MWCNTs with different N atomic percentages was assessed by cellular adhesion investigation using human endothelial cells (EAHY926) and mouse fibroblast cells (L929), respectively. The results showed that the presence of nitrogen in MWCNTs accelerated cell growth and proliferation of cell culture. The higher nitrogen content of N+-bombarded MWCNTs, the better cytocompatibility. In addition, N+-bombarded MWCNTs with higher N atomic percentage displayed lower platelet adhesion rate. No hemolysis can be observed on the surfaces. These results proved that higher N atomic percentage led N+-bombarded MWCNTs to better hemocompatibility.

Keywords:
N+-bombarded multi-walled carbon nanotubes; Nitrogen atomic percentage; Ion beam-assisted deposition; Cytocompatibility; Hemocompatibility