IFN-γ ELISPOT results from gp100 AuNV induction of pmel-1 splenocytes. At 1011 particles/ml or 25 μg/ml, AuNVs stimulated threefold more IFN-γ secreting cells compared to the free-peptide control. At 1010 particles/ml or 2.5 μg/ml maximum dose, the gp100 AuNVs exhibited similar effects as the free-peptide control (10 μg/ml) with no significant difference (p = 0.4).
Lin et al. Nanoscale Research Letters 2013 8:72 doi:10.1186/1556-276X-8-72