Images of nanoparticles and lung tissue. 1-1: TEM images of engineered nanoparticles (A) SiO2, (B) Fe3O4, and (C) SWCNTs. 1-2: Lung tissue from rats instilled with 2 (top) and 10 mg/kg (bottom) of a test material and euthanized 5 weeks after the single treatment. (A) Control group, (B) 2 mg/kg and (E) 10 mg/kg nano-SiO2, and (C) 2 mg/kg and (F) 10 mg/kg nano-Fe3O4. Particles were scattered in alveoli, and granulomas contained black particles (peaky arrow). (D) 2 mg/kg and (G) 10 mg/kg SWCNTs. An aggregate of inflammation cells (lymphocytes) (rotund arrow) around an area surrounded by quartz particle-containing, brown pellets were scattered in lung tissue. Magnifications were × 156.
Lin et al. Nanoscale Research Letters 2013 8:521 doi:10.1186/1556-276X-8-521