MR imaging to assess intratumoral distributions of NChitosan-DMNPs in tumor-bearing mice and comparative therapeutic efficacy. (a)T2-weighted MR images of tumor-bearing mice after intravenous injection of NChitosan-DMNPs. Tumor regions are indicated with a yellow line boundary. (b) Comparative therapeutic efficacy study in the in vivo model (black, NChitosan-DMNPs; gray, DOX; white, saline). Red arrowheads indicate the therapeutic dosing schedule of each therapeutic condition (NChitosan-DMNPs, DOX, and saline).
Lim et al. Nanoscale Research Letters 2013 8:467 doi:10.1186/1556-276X-8-467