Table 1

Physicochemical properties of uncoated and lipid-coated SPIONs in different buffer solutions at pH 7.4
Buffer system Particle concentration (mg/mL) Particle size (nm) Zeta potential (mV)
Uncoated SPIONs Lipid-coated SPIONs Uncoated SPIONs Lipid-coated SPIONs
1.0 520.0 ± 45.4 651.6 ± 25.3 -32.4 ± 1.0 -11.9 ± 1.4
Citrate, pH 7.4 0.24 286.6 ± 25.4 460.3 ± 15.4 -40.7 ± 1.4 -15.6 ± 1.4
0.02 80.0 ± 1.7* 179.3 ± 35.0** -47.1 ± 2.6* -19.1 ± 1.3**
1.0 1860.0 ± 180.9a 2422.0 ± 223.5a -11.2 ± 1.0 -4.5 ± 0.9
HBSS, pH 7.4 0.24 1255.0 ± 35.2a 1560.0 ± 135.2a -12.3 ± 1.1 -5.5 ± 1.0
0.02 580.0 ± 8.5 193.5 ± 32.6** -23.3 ± 0.8 -7.4 ± 1.4
1.0 2800.0 ± 320.4a 2990.0 ± 412.5a -10.3 ± 0.5 -2.2 ± 0.6
PBS, pH 7.4 0.24 2214.0 ± 45.3a 2500.0 ± 245.3a -10.8 ± 1.0 -3.4 ± 1.1
0.02 931.0 ± 4.5 229.9 ± 12.42** -22.5 ± 0.8 -5.2 ± 1.6

Data are represented as mean ± SD (n = 4).

aValue outside qualification range of Zetasizer Nano-ZS.

*Significantly different from uncoated control SPIONs (p < 0.05).

**Significantly different from lipid-coated SPIONs (p < 0.05).

Allam et al.

Allam et al. Nanoscale Research Letters 2013 8:426   doi:10.1186/1556-276X-8-426

Open Data