VLP H1 and VLP H2 suppressed tumor growth in a xenograft model of human breast cancer. Female nude mice (5 to 6 weeks old) were injected subcutaneously with 1 × 106 MDA-MB231 breast cancer cells into the left and right mammary glands of each animal. Tumor size was measured daily or every other day with calipers, and tumor volumes were calculated using the formula: Volume = (width)2 × length/2. After the tumors had established, mice were treated with 10 mg/kg of VLP H1 or VLP H2 (6 days per week) by intraperitoneal injection for 3 weeks. VLP H1 and VLP H2 inhibited tumor growth (A), reduced mouse weight (B), and tumor volumes (C) but did not decrease mouse body weights (D).
Li et al. Nanoscale Research Letters 2013 8:401 doi:10.1186/1556-276X-8-401