Histological analysis of kidney tissues in multi-dose snPt1- or snPt8-treated mice. (A) Vehicle or test article (snPt1 or snPt8 at 10 mg/kg) was administered intraperitoneally to mice as twice-weekly doses for 4 weeks. At 72 h after last administration, the kidney and liver were collected and fixed with 4% paraformaldehyde. Tissue sections were stained with hematoxylin and eosin and observed under a microscope. (B) Chronic kidney injury scores in mice treated with vehicle, snPt1, or snPt8. Grade 0: none, 1: slight, 2: mild, 3: moderate, 4: severe.
Yamagishi et al. Nanoscale Research Letters 2013 8:395 doi:10.1186/1556-276X-8-395