Open Access Nano Express

Acute and chronic nephrotoxicity of platinum nanoparticles in mice

Yoshiaki Yamagishi1, Akihiro Watari1*, Yuya Hayata1, Xiangru Li1, Masuo Kondoh1, Yasuo Yoshioka2, Yasuo Tsutsumi2 and Kiyohito Yagi1

1 Laboratories of Bio-Functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan

2 Laboratories of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan

For all author emails, please log on.

Nanoscale Research Letters 2013, 8:395  doi:10.1186/1556-276X-8-395

Published: 23 September 2013

Additional files

Additional file 1: Figure S1:

Cytotoxicity of snPt1 in renal cells. MDCK cells were treated with vehicle, snPt1, or snPt8 at 0, 10, 20, 40, or 60 μg/ml. After 24 h exposure, morphology of the cells was photographed. Higher magnification images are shown in the insets.

Format: PPT Size: 608KB Download file

This file can be viewed with: Microsoft PowerPoint Viewer

Open Data

Additional file 2: Figure S2:

(A) Histological analysis of kidney tissues in intraperitoneally administered mice. Vehicle or test article (snPt1 or snPt8 at 10 mg/kg) was administered intraperitoneally to mice as a single dose. At 24 h after administration, kidneys were collected and fixed with 4% paraformaldehyde. Tissue sections were stained with hematoxylin and eosin and observed under a microscope. (B) Acute kidney injury score in mice treated intraperitoneally with vehicle, snPt1, or snPt8. Grade 0: none, 1: slight, 2: mild, 3: moderate, 4: severe.

Format: PPT Size: 202KB Download file

This file can be viewed with: Microsoft PowerPoint Viewer

Open Data