Table 2

Available works on the production of solid lipid particles by supercritical fluid technology
Method Lipid composition Active ingredient Particle size Ref
Supercritical fluid-based coating Gelucire® 50/02 Bovine serum albumin 125 to 500 μm [58]
Trimyristin Bovine serum albumin ~50 μm [58]
Supercritical fluid extraction of emulsions Gelucire® 50/13, tripalmitin, or tristearin Indomethacin or ketoprofen ~30 nm [59]
Supercritical co-injection process Precirol® ATO 5 Pseudoephedrine chlorhydrate or bovine serum albumin ~60 μm [60]
Particles from gas-saturated solutions Hydrogenated palm oil Theophylline ~3 μm [61]
Glycerylmonostearate Caffeine ~5 μm [62]
Glycerylmonostearate and Cutina® HR Caffeine, glutathione, or ketoprofen NM [63]
Precirol® ATO 5 and/or Gelucire® 50/13 Trans-chalcone 1 to 6 μm [64]
Glycerylmonostearate and Cutina® HR Ketoprofen NM [65]
Precirol® ATO 5 Ascorbic acid ~2 μm
Myristic acid or tripalmitin Ibuprofen 2 to 4 μm [66]
Beeswax Menthol ~2 to 50 μm [67]
Ceramide 3A, cholesterol, and Radiacid® - 200 to 500 nm [68]
Tristearin and Epikuron 200® Insulin or recombinant human growth hormone ~197 nm [69]
Tristearin and Epikuron 200® or tristearin, Epikuron 200, and PEG Insulin 80 to 120 nm [70]
Tristearin, Epikuron 200®, and oleic acid Magnetite nanoparticles 200 to 800 nm [71]
Tristearin and Epikuron 200® Ribonuclease A functionalized or not with PEG5000 4 to 13 μm [72]

NM, not measured.

Santo et al.

Santo et al. Nanoscale Research Letters 2013 8:386   doi:10.1186/1556-276X-8-386

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