Table 1

Different supercritical fluid methods utilized for liposomes production
Method Phospholipid composition Active ingredient Particle size Reference
Supercritical liposome method Phosphatidylcholine, phosphatidylserine, and cholesterol FITC-dextran and TSZnPc ~200 nm [27]
Rapid expansion of supercritical solution process Phosphatidylcholine and cholesterol Atractylodes macrocephala essential oil ~173 nm [28]
Depressurization of an expanded solution into aqueous media Diastearoylphosphatidylcholine and cholesterol - 50 to 200 nm [29]
Solution-enhanced dispersion by supercritical fluid process Soy phospholipids Puerarin 1 μm [30,31]
Gas anti-solvent process Soy phospholipids - - [31]
Phosphatidylcholine and cholesterol Amphotericin B 0.5 to 3 μm [32]
Aerosol solvent extraction system Phosphatidylcholine and cholesterol Miconazole DNS [33]
Supercritical anti-solvent process Lecithins S20, S75, and S100 - 1 to 40 μm [34]
Lecithin S75 - 1 to 40 μm [35]
Lecithin S75 Fluorescent markers 0.1 to 100 μm [26]
Hydrogenated soy phosphatidylcholine, soy phosphatidylcholine, and cholesterol Docetaxel 200 to 300 nm [36]
Hydrogenated soy phosphatidylcholine Vitamin D3 1 μm [37]
Hydrogenated soy phosphatidylcholine Lutein 200 to 500 nm [38]
Continuous anti-solvent process Soy lecithin - 0.1 to 100 μm [39,40]
Supercritical reverse-phase evaporation Dipalmitoylphosphatidylcholine Glucose and cholesterol 0.1 to 1.2 μm [41]
Phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, and phosphatidic acid Glucose and cholesterol 0.1 to 1.2 μm [42]
Phosphatidylcholine and dioleoylphosphatidylcholine Glucose 0.1 to 1.2 μm [14]
Improved supercritical reverse-phase evaporation Dipalmitoylphosphatidylcholine Glucose 1.5 μm [43,44]

DNS, data not shown.

Santo et al.

Santo et al. Nanoscale Research Letters 2013 8:386   doi:10.1186/1556-276X-8-386

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