Table 3

Cytotoxicity of PBH-capped AuNPs following 24- and 48-h exposure (EMEM/S-), using resazurin assay
Exposure concentration (μg/ml)
Exposure duration AuNP 12.5 25 50 100
Au[(Gly-Trp-Met)2B] 24 h 97 ± 1 97 ± 1* 96 ± 1* 94 ± 0.3**a
  Viability (%) 48 h 98 ± 1 98 ± 2 91 ± 1 69 ± 4**a
  Measured interference (%) 96 ± 2 95 ± 2 94 ± 4 88 ± 4
Au[(Gly-Tyr-TrCys)2B] 24 h 98 ± 1 96 ± 1* 93 ± 1** 90 ± 1**
  Viability (%) 48 h 95 ± 2 100 ± 2 95 ± 3 87 ± 2*
  Measured interference (%) 96 ± 3 90 ± 6 85 ± 7 76 ± 6
Au[(Gly-Tyr-Met)2B] 24 h 96 ± 1 96 ± 1* 96 ± 1* 91 ± 2**a
  Viability (%) 48 h 94 ± 1 91 ± 6* 81 ± 6** 71 ± 5**a
  Measured interference (%) 95 ± 2 92 ± 2 90 ± 4 88 ± 4
Au[(Met)2B] 24 h 97 ± 1 96 ± 0.4* 93 ± 0.4** 94 ± 2**a
  Viability (%) 48 h 97 ± 1 91* ± 3 88 ± 4** 68 ± 4 **a
  Measured interference (%) 93 ± 1 91± 91 ± 2 89 ± 5
Au[(TrCys)2B] 24 h 98 ± 1 97 ± 1 92 ±2* 88 ± 1**
  Viability (%) 48 h 94 ± 4 93 ± 1 88 ± 2 ** 77 ± 1**
  Measured interference (%) 95 ± 1 93± 91 ± 3 87 ± 4

Also shown are the measured interferences in percent (%) of the control. Average values of three independent measurements are presented (mean ± SEM). Bold emphasis is used to signal the most stable AuNP; *P < 0.05 and **P < 0.01, significant differences from control values. aSignificant differences between response to 24- and 48-h exposure.

Connolly et al.

Connolly et al. Nanoscale Research Letters 2013 8:315   doi:10.1186/1556-276X-8-315

Open Data