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Peptide-biphenyl hybrid-capped AuNPs: stability and biocompatibility under cell culture conditions

Mona Connolly1, Yolanda Pérez2*, Enrique Mann3, Bernardo Herradón3, María L Fernández-Cruz1* and José M Navas1

1 Departamento de Medio Ambiente, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Carretera de la Coruña Km 7.5, Madrid 28040, Spain

2 Universidad Rey Juan Carlos, Tulipán s/n, Móstoles, Madrid 28933, Spain

3 Consejo Superior de Investigaciones Científicas (CSIC), Instituto de Química Orgánica General, Juan de la Cierva 3, Madrid 28006, Spain

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Nanoscale Research Letters 2013, 8:315  doi:10.1186/1556-276X-8-315

Published: 6 July 2013

Additional files

Additional file 1:

Synthesis of PBHs.

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Additional file 2: Figure S1:

1H NMR spectrum of free PBH (Met)2B (top) in DMSO-d6 and 1H NMR spectrum of AuNP Au[(Met)2B] (bottom) in D2O.

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Additional file 3: Figure S2:

UV–vis absorption spectra of AuNPs (a) Au[(Gly-Tyr-Met)2B], (b) Au[(Gly-Tyr-TrCys)2B], (c) Au[(Gly-Trp-Met)2B], (d) Au[(Met)2B] and (e) Au[(TrCys)2B], in water and EMEM/+, each at a concentration of 100 μg/ml and a different time 0, 2, 4 and 24 h after incubation at 37°C.

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