Figure 4.

Fold changes in gene expression: apoptosis, adhesion molecules, ER stress, oxidative stress, and calcium-handling proteins. The changes of HAECs incubated with 0.02 mg/ml DMSA-Fe2O3 for 24 h to control the cells (HAECs without DMSA-Fe2O3) were analyzed by the 2-ΔΔCT method. Gene symbols and corresponding encoded proteins: MAP3K5, apoptosis signal-regulating kinase 1 (ASK1); TRAF2, tumor necrosis factor receptor-associated factor 2 (TRAF2); DAB2IP, ASK1-interacting protein (AIP1); MAPK8, mitogen-activated protein kinase 8 (JNK1); MAPK9, mitogen-activated protein kinase 9 (JNK2); MAPK14, mitogen-activated protein kinase 14 (p38 MAPK α); ERN1, endoplasmic reticulum to nucleus signaling 1 (IRE1); BCL2, B-cell lymphoma 2 (Bcl-2); BAX, Bcl-2-associated X protein (Bax); NKRF, nuclear factor-κB repressing factor; TXN, thioredoxin; CTSB, cathespin B; CYCS, cytochrome C; CASP9, caspase-9; CASP3, caspase-3; EIF2AK3, eukaryotic translation initiation factor 2α kinase 3 (PERK); ATF4, activating transcription factor 4; DDIT3, DNA-damage-inducible transcript 3 (CHOP); EIF2A, eukaryotic translation initiation factor 2α; NOS3, nitric oxide synthase 3 (eNOS); SOD1, super oxide dismutase 1 (SOD-1); SOD2, super oxide dismutase 2 (SOD-2); ROMO1, reactive oxygen species modulator 1; PTGS1, cyclooxygenase 1 (COX-1); PTGS2, cyclooxygenase 2 (COX-2); VCAM1, vascular cell adhesion molecule 1 (VCAM-1); ICAM1, intercellular adhesion molecule 1(ICAM-1); ICAM2, intercellular adhesion molecule 2 (ICAM-2); SELE, endothelial-leukocyte adhesion molecule 1 (E-selectin); PLCG1, phospholipase C γ1; PLCG2, phospholipase C γ2; ITPR1, inositol 1,4,5-trisphosphate receptor type 1; ITPR2, inositol 1,4,5-trisphosphate receptor type 2; ITPR3, inositol 1,4,5-trisphosphate receptor type 3; CALM1, calmodulin 1.

Ge et al. Nanoscale Research Letters 2013 8:215   doi:10.1186/1556-276X-8-215
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