Open Access Nano Express

Cytotoxicity and variant cellular internalization behavior of water-soluble sulfonated nanographene sheets in liver cancer cells

Stuart J Corr123, Mustafa Raoof1, Brandon T Cisneros1, Oleksandr Kuznetsov34, Katheryn Massey1, Warna D Kaluarachchi1, Matthew A Cheney23, Edward W Billups2, Lon J Wilson23 and Steven A Curley156*

1 Department of Surgical Oncology, University of Texas M. D. Anderson Cancer Center, Unit 107, Rm. T4.3936, 6767 Bertner, Houston, TX, 77030, USA

2 Department of Chemistry, Rice University, Houston, TX, 77005, USA

3 Richard E. Smalley Institute for Nanoscale Science and Technology, Rice University, Houston, TX, 77005, USA

4 Department of Physics and Astronomy, Rice University, Houston, TX, 77005, USA

5 Department of Mechanical Engineering and Materials Science, Rice University, Houston, TX, 77005, USA

6 Division of Surgery, University of Texas M. D. Anderson Cancer Center, Unit 1447, 1400 Pressler Street, Houston, TX, 77230-1402, USA

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Nanoscale Research Letters 2013, 8:208  doi:10.1186/1556-276X-8-208

Published: 2 May 2013

Additional files

Additional file 1:

Supplementary information. Figure S1: AFM images of SGSs, Figure S2: Raman spectra, Figure S3: XPS spectra, Figure S4: TGA of completely exfoliated SGSs, Figure S5: FACS analysis, Figure S6: SEM image, and Figure S7: magnified view of Figure 5B (maintext).

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Additional file 2:

Hep3B SGS movie. Movie sequence of SGS internalization over a 17-h time period. Cell lines are Hep3B.

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Additional file 3:

Hep3B control movie. Movie sequence of Hep3B control (no SGS exposure) across a 17-h time period.

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