NH2 + implantations induced superior hemocompatibility of carbon nanotubes
1 College of Physics and Electronic Information Science, Tianjin Normal University, Tianjin, 300387, China
2 Department of Mechanical & Materials Engineering, University of Western Ontario, London, ON, Canada
3 Tianjin Institute of Urological Surgery, Tianjin Medical University, Tianjin 300070, China
4 Ninth People’s Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, China
Citation and License
Nanoscale Research Letters 2013, 8:205 doi:10.1186/1556-276X-8-205Published: 1 May 2013
NH2+ implantation was performed on multiwalled carbon nanotubes (MWCNTs) prepared by chemical vapor deposition. The hemocompatibility of MWCNTs and NH2+-implanted MWCNTs was evaluated based on in vitro hemolysis, platelet adhesion, and kinetic-clotting tests. Compared with MWCNTs, NH2+-implanted MWCNTs displayed more perfect platelets and red blood cells in morphology, lower platelet adhesion rate, lower hemolytic rate, and longer kinetic blood-clotting time. NH2+-implanted MWCNTs with higher fluency of 1 × 1016 ions/cm2 led to the best thromboresistance, hence desired hemocompatibility. Fourier transfer infrared and X-ray photoelectron spectroscopy analyses showed that NH2+ implantation caused the cleavage of some pendants and the formation of some new N-containing functional groups. These results were responsible for the enhanced hemocompatibility of NH2+-implanted MWCNTs.