Open Access Nano Express

NH2 + implantations induced superior hemocompatibility of carbon nanotubes

Meixian Guo1, Dejun Li1*, Mengli Zhao1, Yiteng Zhang1, Xiangyun Deng1, Dongsheng Geng2, Ruying Li2, Xueliang Sun2, Hanqing Gu34 and Rongxin Wan3

Author Affiliations

1 College of Physics and Electronic Information Science, Tianjin Normal University, Tianjin, 300387, China

2 Department of Mechanical & Materials Engineering, University of Western Ontario, London, ON, Canada

3 Tianjin Institute of Urological Surgery, Tianjin Medical University, Tianjin 300070, China

4 Ninth People’s Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, China

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Nanoscale Research Letters 2013, 8:205  doi:10.1186/1556-276X-8-205

Published: 1 May 2013

Abstract

NH2+ implantation was performed on multiwalled carbon nanotubes (MWCNTs) prepared by chemical vapor deposition. The hemocompatibility of MWCNTs and NH2+-implanted MWCNTs was evaluated based on in vitro hemolysis, platelet adhesion, and kinetic-clotting tests. Compared with MWCNTs, NH2+-implanted MWCNTs displayed more perfect platelets and red blood cells in morphology, lower platelet adhesion rate, lower hemolytic rate, and longer kinetic blood-clotting time. NH2+-implanted MWCNTs with higher fluency of 1 × 1016 ions/cm2 led to the best thromboresistance, hence desired hemocompatibility. Fourier transfer infrared and X-ray photoelectron spectroscopy analyses showed that NH2+ implantation caused the cleavage of some pendants and the formation of some new N-containing functional groups. These results were responsible for the enhanced hemocompatibility of NH2+-implanted MWCNTs.

Keywords:
Multiwalled carbon nanotubes; Ion implantation; Hemocompatibility; Functional group