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Open Access Nano Express

Self-assembly of gold nanoparticles to silver microspheres as highly efficient 3D SERS substrates

Shouhui Chen12, Peng Huang2, Zhihua Wang2, Zhe Wang2, Magdalena Swierczewska2, Gang Niu2, Daxiang Cui1* and Xiaoyuan Chen2*

Author Affiliations

1 Department of Bio-Nano-Science and Engineering, National Key Laboratory of Nano/Micro Fabrication Technology, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai JiaoTong University, Shanghai, 200240, China

2 Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD, 20892, USA

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Nanoscale Research Letters 2013, 8:168  doi:10.1186/1556-276X-8-168

Published: 12 April 2013


Herein we report a simple, one-pot, surfactant-free synthesis of 3D Ag microspheres (AgMSs) in aqueous phase at room temperature. The 3D AgMSs act as supports to fix the gold nanoparticles (GNPs) in 3D space via the interaction between the carboxyl groups of GNPs and the Ag atoms of AgMSs. The ensemble of AgMSs@GNPs with high surface-enhanced Raman scattering (SERS) activity and sensitivity can be an ideal 3D substrate choice for practical SERS detection applications. The simple self-assembly strategy may be extended to other metallic materials with great potentials in SERS, catalysis, and photoelectronic devices.

Self-assembly; Gold nanoparticles; Silver microspheres; SERS