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Optimized gold nanoshell ensembles for biomedical applications

Debabrata Sikdar1, Ivan D Rukhlenko1*, Wenlong Cheng23 and Malin Premaratne1

Author Affiliations

1 Advanced Computing and Simulation Laboratory (A χL), Department of Electrical and Computer Systems Engineering, Monash University, Clayton 3800, Victoria, Australia

2 Department of Chemical Engineering, Faculty of Engineering, Monash University, Clayton 3800, Victoria, Australia

3 , The Melbourne Centre for Nanofabrication, 151 Wellington RoadClayton 3168, Victoria, Australia

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Nanoscale Research Letters 2013, 8:142  doi:10.1186/1556-276X-8-142

Published: 28 March 2013


We theoretically study the properties of the optimal size distribution in the ensemble of hollow gold nanoshells (HGNs) that exhibits the best performance at in vivo biomedical applications. For the first time, to the best of our knowledge, we analyze the dependence of the optimal geometric means of the nanoshells’ thicknesses and core radii on the excitation wavelength and the type of human tissue, while assuming lognormal fit to the size distribution in a real HGN ensemble. Regardless of the tissue type, short-wavelength, near-infrared lasers are found to be the most effective in both absorption- and scattering-based applications. We derive approximate analytical expressions enabling one to readily estimate the parameters of optimal distribution for which an HGN ensemble exhibits the maximum efficiency of absorption or scattering inside a human tissue irradiated by a near-infrared laser.

Hollow gold nanoshells; Lognormal distribution; Absorption; Scattering; Biomedical applications