Table 2

Benefits of drug load in liposomes
Benefits of drug load in liposome Examples
1. Improved solubility of lipophilic and amphiphilic drugs Amphotericin B, porphyrins, minoxidil, some peptides, and anthracyclines, respectively; hydrophilic drugs, such as anticancer agent doxorubicin or acyclovir
2. Passive targeting to the cells of the immune system, especially cells of the mononuclear phagocytic system Antimonials, amphotericin B, porphyrins, vaccines, immunomodulators
3. Sustained release system of systemically or locally administered liposomes Doxorubicin, cytosine arabinoside, cortisones, biological proteins or peptides such as vasopressin
4. Site-avoidance mechanism Doxorubicin andamphotericin B
5. Site-specific targeting Anti-inflammatory drugs, anti-cancer, anti-infection
6. Improved transfer of hydrophilic, charged molecules Antibiotics, chelators, plasmids, and genes
7. Improved penetration into tissues Corticosteroids, anesthetics, and insulin

Akbarzadeh et al.

Akbarzadeh et al. Nanoscale Research Letters 2013 8:102   doi:10.1186/1556-276X-8-102

Open Data