Table 1
Advantages and disadvantages of liposome [ 19]
Advantages of liposome	Disadvantages of liposome
Liposomes increased efficacy and therapeutic index of drug (actinomycin-D)	Low solubility
Liposome increased stability via encapsulation	Short half-life
Liposomes are non-toxic, flexible, biocompatible, completely biodegradable, and non-immunogenic for systemic and non-systemic administrations	Sometimes phospholipid undergoes oxidation and hydrolysis-like reaction
Liposomes reduce the toxicity of the encapsulated agent (amphotericin B, Taxol)	Leakage and fusion of encapsulated drug/molecules
Liposomes help reduce the exposure of sensitive tissues to toxic drugs	Production cost is high
Site avoidance effect	Fewer stables
Flexibility to couple with site-specific ligands to achieve active targeting

Akbarzadeh et al. Nanoscale Research Letters 2013 8:102   doi:10.1186/1556-276X-8-102