SWNHs inhibited growth and proliferation of N9 cells, especially in pre-treated with LPS. By XTT assays, we investigated the effect of SWNHs on cell growth and found that the growth of N9 cells pre-treated with LPS (B) was much more significantly than N9 cells (A). The growth of cells were significantly inhibited by SWNHs at each time point in a dose-dependent manner (P < 0.001), especially in cells pre-treated with LPS (B). Cell viability was evaluated by CCK-8 assay. The result showed that the proliferation of N9 cells pre-treated with LPS (D) was much more significantly than N9 cells (C). The proliferation of N9 cells treated with SWNHs was significantly inhibited at each time point in a time and dose-dependent manner (C and D). The effect induced by SWNHs on N9 cells pre-treated with LPS (D) was far more than that cells pre-treated without LPS (B). All data are represented as mean ± SEM.
Li et al. Nanoscale Research Letters 2013 8:100 doi:10.1186/1556-276X-8-100