Open Access Nano Express

Antitumor activity of sorafenib-incorporated nanoparticles of dextran/poly(dl-lactide-co-glycolide) block copolymer

Do Hyung Kim12, Min-Dae Kim3, Cheol-Woong Choi3, Chung-Wook Chung1, Seung Hee Ha1, Cy Hyun Kim12, Yong-Ho Shim1, Young-Il Jeong1* and Dae Hwan Kang12*

Author Affiliations

1 National Research & Development Center for Hepatobiliary Cancer, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Beomeo-ri, Mulgeum-eup, Yangsan, 626-770, Republic of Korea

2 School of Medicine, Pusan National University, Yangsan, 626-770, Republic of Korea

3 Department of Internal Medicine, Medical Research Institute, Pusan National University School of Medicine and Medical Research Institute, Yangsan, 626-770, Republic of Korea

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Nanoscale Research Letters 2012, 7:91  doi:10.1186/1556-276X-7-91

Published: 27 January 2012

Abstract

Sorafenib-incoporated nanoparticles were prepared using a block copolymer that is composed of dextran and poly(DL-lactide-co-glycolide) [DexbLG] for antitumor drug delivery. Sorafenib-incorporated nanoparticles were prepared by a nanoprecipitation-dialysis method. Sorafenib-incorporated DexbLG nanoparticles were uniformly distributed in an aqueous solution regardless of the content of sorafenib. Transmission electron microscopy of the sorafenib-incorporated DexbLG nanoparticles revealed a spherical shape with a diameter < 300 nm. Sorafenib-incorporated DexbLG nanoparticles at a polymer/drug weight ratio of 40:5 showed a relatively uniform size and morphology. Higher initial drug feeding was associated with increased drug content in nanoparticles and in nanoparticle size. A drug release study revealed a decreased drug release rate with increasing drug content. In an in vitro anti-proliferation assay using human cholangiocarcinoma cells, sorafenib-incorporated DexbLG nanoparticles showed a similar antitumor activity as sorafenib. Sorafenib-incorporated DexbLG nanoparticles are promising candidates as vehicles for antitumor drug targeting.

Keywords:
sorafenib; polymeric micelle; dextran; poly(DL-lactide-co-glycolide)