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Modified wound dressing with phyto-nanostructured coating to prevent staphylococcal and pseudomonal biofilm development

Ion Anghel16, Alina Maria Holban2, Alexandru Mihai Grumezescu3*, Ecaterina Andronescu3, Anton Ficai3, Alina Georgiana Anghel4, Maria Maganu5, Veronica Lazǎr2 and Mariana Carmen Chifiriuc2

Author Affiliations

1 ENT (Otolaryngology) Department, Coltea Hospital, Carol Davila University of Medicine and Pharmacy, IC Bratianu No. 1, Bucharest, 030171, Romania

2 Department of Microbiology, Faculty of Biology, Universtity of Bucharest, Aleea Portocalelor No. 1-3, Bucharest, 060101, Romania

3 Department of Science and Engineering of Oxidic Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Polizu Street No. 1-7, Bucharest, 011061, Romania

4 ENT (Otolaryngology) Department, Coltea Hospital, Carol Davila University of Medicine and Pharmacy, IC Bratianu no 1, 030171, Bucharest, Romania

5 Center of Organic Chemistry “Costin D. Nenitescu”, Romanian Academy, 202B Splaiul Independentei, Bucharest, 050461, Romania

6 Doctor Anghel Medical Center, Theodor Sperantia Street, Bucharest, 30932, Romania

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Nanoscale Research Letters 2012, 7:690  doi:10.1186/1556-276X-7-690

Published: 31 December 2012


This paper reports a newly fabricated nanophyto-modified wound dressing with microbicidal and anti-adherence properties. Nanofluid-based magnetite doped with eugenol or limonene was used to fabricate modified wound dressings. Nanostructure coated materials were characterized by TEM, XRD, and FT-IR. For the quantitative measurement of biofilm-embedded microbial cells, a culture-based method for viable cell count was used. The optimized textile dressing samples proved to be more resistant to staphylococcal and pseudomonal colonization and biofilm formation compared to the uncoated controls. The functionalized surfaces for wound dressing seems to be a very useful tool for the prevention of wound microbial contamination on viable tissues.

Magnetite nanoparticles; Eugenol; Limonene; Wound dressing