Figure 2.

The size of different NPs (mean ± SD) (A). ANPs: TPGS-b-(PCL-ran-PGA) NPs; DNPs: docetaxel-loaded TPGS-b-(PCL-ran-PGA) NPs; ENPs: docetaxel-loaded TPGS-b-(PCL-ran-PGA)/PEI. The results showed that the size of NPs increased because of loading docetaxel and/or being modified by PEI. The zeta potential of the different NPs (B). The zeta potential of blank NPs was negative; the zeta potential of the NPs modified by PEI was positive and reduced after complexed with pDNA. The results showed that TPGS-b-(PCL-ran-PGA) blank NPs could be modified. Gel retardation assay of pDNA complexed with TPGS-b-(PCL-ran-PGA)/PEI (C). Each lane contained the same pDNA. Surface morphology of the PEI-modified TPGS-b-(PCL-ran-PGA) NPs was examined by FESEM (D).