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Nanomechanical characterization of chemical interaction between gold nanoparticles and chemical functional groups

Gyudo Lee12, Hyungbeen Lee2, Kihwan Nam12, Jae-Hee Han3, Jaemoon Yang4, Sang Woo Lee2, Dae Sung Yoon2, Kilho Eom12 and Taeyun Kwon12*

Author affiliations

1 Institute for Molecular Sciences, Seoul, 120-749, Republic of Korea

2 Department of Biomedical Engineering, Yonsei University, Wonju, 220-710, Republic of Korea

3 Department of Energy IT, Gachon University, Seongnam, Gyeonggi-do, 461-701, Republic of Korea

4 Department of Radiology, College of Medicine, Yonsei University, Seoul, 120-749, Republic of Korea

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Citation and License

Nanoscale Research Letters 2012, 7:608  doi:10.1186/1556-276X-7-608

Published: 31 October 2012


We report on how to quantify the binding affinity between a nanoparticle and chemical functional group using various experimental methods such as cantilever assay, PeakForce quantitative nanomechanical property mapping, and lateral force microscopy. For the immobilization of Au nanoparticles (AuNPs) onto a microscale silicon substrate, we have considered two different chemical functional molecules of amine and catecholamine (here, dopamine was used). It is found that catecholamine-modified surface is more effective for the functionalization of AuNPs onto the surface than the amine-modified surface, which has been shown from our various experiments. The dimensionless parameter (i.e., ratio of binding affinity) introduced in this work from such experiments is useful in quantitatively depicting such binding affinity, indicating that the binding affinity and stability between AuNPs and catecholamine is approximately 1.5 times stronger than that between amine and AuNPs. Our study sheds light on the experiment-based quantitative characterization of the binding affinity between nanomaterial and chemical groups, which will eventually provide an insight into how to effectively design the functional material using chemical groups.

Au nanoparticle; Dopamine; Surface chemistry; Atomic force microscopy; Lateral force microscopy