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Synthesis and characterization of polysaccharide-maghemite composite nanoparticles and their antibacterial properties

Simona Liliana Iconaru1, Alina Mihaela Prodan23, Mikael Motelica-Heino4, Stanislas Sizaret4 and Daniela Predoi1*

Author Affiliations

1 National Institute of Materials Physics, 105 bis Atomistilor, P.O. Box MG 07, Bucharest-Magurele, 077125, Romania

2 Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari, sector 5, Bucharest, Romania

3 Emergency Hospital Floreasca, Bucharest 5, Calea Floresca nr 8, sector 1, Bucharest, Romania

4 ISTO, Université d’Orléans, Orléans cedex 02, 45067, France

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Nanoscale Research Letters 2012, 7:576  doi:10.1186/1556-276X-7-576

Published: 22 October 2012


The aim of this study was to obtain saccharide (dextran and sucrose)-coated maghemite nanoparticles with antibacterial activity. The polysaccharide-coated maghemite nanoparticles were synthesized by an adapted coprecipitation method. X-ray diffraction (XRD) studies demonstrate that the obtained polysaccharide-coated maghemite nanoparticles can be indexed into the spinel cubic lattice with a lattice parameter of 8.35 Å. The refinement of XRD spectra indicated that no other phases except the maghemite are detectable. The characterization of the polysaccharide-coated maghemite nanoparticles by various techniques is described. The antibacterial activity of these polysaccharide-coated maghemite nanoparticles (NPs) was tested against Pseudomonas aeruginosa 1397, Enterococcus faecalis ATCC 29212, Candida krusei 963, and Escherichia coli ATCC 25922 and was found to be dependent on the polysaccharide type. The antibacterial activity of dextran-coated maghemite was significantly higher than that of sucrose-coated maghemite. The antibacterial studies showed the potential of dextran-coated iron oxide NPs to be used in a wide range of medical infections.

Iron oxides; Biological polymers; Antibacterial activity