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In vitro evaluation of anti-pathogenic surface coating nanofluid, obtained by combining Fe3O4/C12 nanostructures and 2-((4-ethylphenoxy)methyl)-N-(substituted-phenylcarbamothioyl)-benzamides

Ion Anghel1, Carmen Limban2, Alexandru Mihai Grumezescu3*, Alina Georgiana Anghel4, Coralia Bleotu5 and Mariana Carmen Chifiriuc6

Author Affiliations

1 ENT (Otolaryngology), Carol Davila University of Medicine and Pharmacy, Bucharest, 50474, Romania

2 Department of Pharmaceutical Chemistry, Carol Davila University of Medicine and Pharmacy, Bucharest, 020956, Romania

3 Department of Science and Engineering of Oxidic Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Bucharest, 011061, Romania

4 ENT Clinic, Coltea Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, 030171, Romania

5 Stefan Nicolau Institute of Virology, Bucharest, 030304, Romania

6 Department of Microbiology, Faculty of Biology, University of Bucharest, Bucharest, 060101, Romania

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Nanoscale Research Letters 2012, 7:513  doi:10.1186/1556-276X-7-513

Published: 19 September 2012

Abstract

In this paper, we report the design of a new nanofluid for anti-pathogenic surface coating. For this purpose, new 2-((4-ethylphenoxy)methyl)-N-(substituted-phenylcarbamothioyl)-benzamides were synthesized and used as an adsorption shell for Fe3O4/C12 core/shell nanosized material. The functionalized specimens were tested by in vitro assays for their anti-biofilm properties and biocompatibility. The optimized catheter sections showed an improved resistance to Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27853 in vitro biofilm development, as demonstrated by the viable cell counts of biofilm-embedded bacterial cells and by scanning electron microscopy examination of the colonized surfaces. The nanofluid proved to be not cytotoxic and did not influence the eukaryotic cell cycle. These results could be of a great interest for the biomedical field, opening new directions for the design of film-coated surfaces with improved anti-biofilm properties.

Keywords:
lauric acid; benzamides; thiourea derivatives; magnetite; anti-biofilm; core/shell nanostructure