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Recognizing nucleosides with transverse electronic transport via perpendicular direction of base planes for DNA sequencing

Bing Yang*, Ruixin Dong, Xunling Yan and Qiang Shi

Author Affiliations

School of Physics Science and Information Technology, Liaocheng University, Liaocheng Shandong, 252059, China

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Nanoscale Research Letters 2012, 7:512  doi:10.1186/1556-276X-7-512

Published: 19 September 2012


Putting the four DNA nucleosides in the middle of gold [111] nanoelectrodes with base planes parallel to the electrode surface layer, we study the transverse electronic transport properties of four nucleosides along the direction of electrodes. First, the optimal distance of the electrodes is released. The results show that the optimal electrode distance to study transverse electronic transport characteristics of DNA nucleosides is about 0.68 nm. Second, we theoretically calculate the conductance and current of the four nucleosides via perpendicular direction of base planes in the bias range of [−2, 2] V by exploiting the first principle theory. According to the calculated results, we propose three methods to recognize the nucleoside type in practice application.

DNA; nucleoside; electronic transport; DNA sequencing.; 87.15.ag, 87.15.pc, 87.85.Qr