Open Access Nano Express

External magnetic field-induced selective biodistribution of magnetoliposomes in mice

Sonia García-Jimeno1, Elvira Escribano24, Josep Queralt34 and Joan Estelrich14*

Author affiliations

1 Departament de Fisicoquímica, Facultat de Farmàcia, Universitat de Barcelona, Avda. Joan XXIII, Barcelona, Catalonia, 08028, Spain

2 Departament de Farmàcia i Tecnologia Farmacèutica, Facultat de Farmàcia, Universitat de Barcelona, Avda. Joan XXIII, Barcelona, Catalonia, 08028, Spain

3 Departament de Fisiologia, Facultat de Farmàcia, Universitat de Barcelona, Avda. Joan XXIII, Barcelona, Catalonia, 08028, Spain

4 Institut de Nanociència i Nanotecnologia de la Universitat de Barcelona (IN2UB), Barcelona, Catalonia, 08028, Spain

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Citation and License

Nanoscale Research Letters 2012, 7:452  doi:10.1186/1556-276X-7-452

Published: 10 August 2012

Abstract

This study looked at the effect of an external magnet on the biodistribution of magnetoliposomes intravenously administrated in mice (8 mg iron/kg) with and without induced acute inflammation. Our results showed that due to enhanced vascular permeability, magnetoliposomes accumulated at the site of inflammation in the absence of an external magnetic field, but the amount of iron present increased under the effect of a magnet located at the inflammation zone. This increase was dependent on the time (20 or 60 min) of exposure of the external magnetic field. It was also observed that the presence of the magnet was associated with lower amounts of iron in the liver, spleen, and plasma than was found in mice in which a magnet had not been applied. The results of this study confirm that it is possible to target drugs encapsulated in magnetic particles by means of an external magnet.

Keywords:
magnetoliposomes; magnetic nanoparticles; inflammation; biodistribution; external magnetic field