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Calpain inhibitor nanocrystals prepared using Nano Spray Dryer B-90

Koichi Baba* and Kohji Nishida

Author Affiliations

Department of Ophthalmology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

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Nanoscale Research Letters 2012, 7:436  doi:10.1186/1556-276X-7-436

Published: 4 August 2012


The Nano Spray Dryer B-90 offers a new, simple, and alternative approach for the production of drug nanocrystals. Among attractive drugs, calpain inhibitor that inhibits programmed cell death ‘apoptosis’ is a candidate for curing apoptosis-mediated intractable diseases such as Alzheimer’s disease and Parkinson’s disease. In this study, the preparation of calpain inhibitor nanocrystals using Nano Spray Dryer B-90 was demonstrated. The particle sizes were controlled by means of selecting mesh aperture sizes. The obtained average particle sizes were in the range of around 300 nm to submicron meter.

Calpain inhibitor; Drug nanocrystals; Nano Spray Dryer B-90; 81.07.Wx; 81.16.-c