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Preparation and optimization of matrix metalloproteinase-1-loaded poly(lactide-co-glycolide-co-caprolactone) nanoparticles with rotatable central composite design and response surface methodology

Ping Sun, Hua Song*, Daxiang Cui, Jun Qi, Mousheng Xu and Hongquan Geng*

Nanoscale Research Letters 2012, 7:359  doi:10.1186/1556-276X-7-359