Open Access Nano Express

Shape engineering vs organic modification of inorganic nanoparticles as a tool for enhancing cellular internalization

Didem Sen Karaman1, Diti Desai12, Rajendran Senthilkumar3, Emma M Johansson4, Natalie Råtts135, Magnus Odén4, John E Eriksson3, Cecilia Sahlgren35, Diana M Toivola36 and Jessica M Rosenholm1*

Author Affiliations

1 Centre for Functional Materials, Laboratory of Physical Chemistry, Department of Natural Sciences, Åbo Akademi University, Porthansgatan 3-5, Turku, FI-20500, Finland

2 Pharmacy Department, Faculty of Tech. & Eng, The M.S. University of Baroda, Vadodara, Gujarat -390002, India

3 Department of Biosciences, Cell biology, Åbo Akademi University, Artillerigatan 6A, Turku FI-20520, Finland

4 Nanostructured Materials Division, Department of Physics, Chemistry and Biology, Linköping University, Linköping, SE-581 83, Sweden

5 Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, P.O. Box 123, Turku FI-20521, Finland

6 Turku Center for Disease Modeling, Kiinamyllynkatu 10, Turku FIN-20520, Finland

For all author emails, please log on.

Nanoscale Research Letters 2012, 7:358  doi:10.1186/1556-276X-7-358

Published: 1 July 2012

Additional files

Additional file 1:

Supplementary methods.

Format: DOCX Size: 21KB Download file

Open Data

Additional file 2:

Figure S1 DLS measurements of nonfluorescent NR-MSPs (red) and S-MSPs (green) measured in water after SDA removal and drying.

Format: TIFF Size: 93KB Download file

Open Data

Additional file 3:

Figure S2 MFI values from FACS for HeLa cells incubated with 10 and 2 μg/mL MSPs for 4 h. The lower graphs have been normalized against pure particle suspension fluorescence values measured at 530 nm in HEPES buffer at pH 7.2.

Format: TIFF Size: 163KB Download file

Open Data

Additional file 4:

Figure S3 MFI values from FACS for Caco-2 cells incubated with 10 and 2 μg/mL MSPs for 4 h. The lower graphs have been normalized against pure particle suspension fluorescence values measured at 530 nm in HEPES buffer at pH 7.2.

Format: TIFF Size: 168KB Download file

Open Data

Additional file 5:

Figure S4 MFI values from FACS for HeLa cells incubated with 1 μg/mL MSPs for 4 h. The right graph has been normalized against pure particle suspension fluorescence values measured at 530 nm in HEPES buffer at pH 7.2.

Format: TIFF Size: 216KB Download file

Open Data