Table 2 |
||
| Pharmacokinetic parameters of insulin in diabetic rats | ||
| SC-administered insulin solution | Orally administered insulin-loaded nanoparticles | |
| Dose (IU/kg) | 5.0 | 50 |
| Cmax (μIU/mL) | 129.21 ± 8.49 | 69.93 ± 7.64 |
| Tmax (h) | 0.33 | 3 |
| AUC(0 to 8 h) (μIU h/mL) | 143.76 ± 21.37 | 161.69 ± 28.58 |
| BAR (%) | 100 | 11.3 ± 1.05 |
Parameters after SC administration of the free-form insulin solution or oral administration of insulin-loaded PLGA/HP55 nanoparticles. AUC, area under the plasma concentration-time curve; BAR, relative bioavailability; Cmax, maximum plasma concentration; Tmax, time at which Cmax is attained. Data are given as mean ± S.D. (n = 3).
Wu et al. Nanoscale Research Letters 2012 7:299 doi:10.1186/1556-276X-7-299
