Table 2

Pharmacokinetic parameters of insulin in diabetic rats
SC-administered insulin solution Orally administered insulin-loaded nanoparticles
Dose (IU/kg) 5.0 50
Cmax (μIU/mL) 129.21 ± 8.49 69.93 ± 7.64
Tmax (h) 0.33 3
AUC(0 to 8 h) (μIU h/mL) 143.76 ± 21.37 161.69 ± 28.58
BAR (%) 100 11.3 ± 1.05

Parameters after SC administration of the free-form insulin solution or oral administration of insulin-loaded PLGA/HP55 nanoparticles. AUC, area under the plasma concentration-time curve; BAR, relative bioavailability; Cmax, maximum plasma concentration; Tmax, time at which Cmax is attained. Data are given as mean ± S.D. (n = 3).

Wu et al.

Wu et al. Nanoscale Research Letters 2012 7:299   doi:10.1186/1556-276X-7-299

Open Data