Table 1

Pharmacokinetic parameters of DHA
Parameters DHA N/O/W emulsion DHA O/W emulsion DHA solution
t1/2α (min) 9.40 ± 0.28*,** 3.97 ± 0.34 3.10 ± 0.09
t1/2β (min) 160.91 ± 47.21*,** 73.31 ± 1.61* 20.20 ± 6.56
Cl (ml·min−1·kg) 0.0023 ± 0.0002*,** 0.0038 ± 0.0002* 0.0069 ± 0.0013
AUC (min·ng·ml−1) 219,759.00 ± 14,782.77*,** 131,564.5 ± 8,396.89* 73,025.35 ± 14,149.00
MRT (min) 97.65 ± 20.27*,** 32.22 ± 4.03* 9.40 ± 2.44

Parameters of DHA after intravenous administration of DHA N/O/W emulsion to rabbits, DHA solution, and DHA O/W emulsion as controls. The results are expressed as mean ± S.D. (n = 6), *P < 0.01 vs. DHA solution, **P < 0.01 vs. DHA O/W emulsion.

Wang et al.

Wang et al. Nanoscale Research Letters 2012 7:219   doi:10.1186/1556-276X-7-219

Open Data