Open Access Nano Express

Effect of MWCNTs on Gastric Emptying in Mice

Z Li, W Qi, YX Geng, DQ Pan, Y Lu, JZ Xu and WS Wu*

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Radiochemistry Laboratory, Lanzhou University, 73000, Lanzhou, People's Republic of China

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Citation and License

Nanoscale Res Lett 2011, 6:63  doi:10.1007/s11671-010-9803-y

Published: 7 October 2010

Abstract

After making model of gastric functional disorder (FD), part of model mice were injected intravenously (i.v.) with oxide multi-walled carbon nanotubes (oMWCNTs) to investigate effect of carbon nanotubes on gastric emptying. The results showed that NO content in stomach, compared with model group, was decreased significantly and close to normal level post-injection with oMWCNTs (500 and 800 μg/mouse). In contrast to FD or normal groups, the content of acetylcholine (Ach) in stomach was increased obviously in injection group with 500 or 800 μg/mouse of oMWCNTs. The kinetic curve of emptying was fitted to calculate gastric motility factor k; the results showed that the k of injection group was much higher than FD and normal. In other words, the gastric motility of FD mice was enhanced via injection with oMWCNTs. In certain dosage, oMWCNTs could improve gastric emptying and motility.

Keywords:
oMWCNTs; Functional disorder; NO; Ach; Gastric emptying