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One-step fabrication of biocompatible chitosan-coated ZnS and ZnS:Mn2+ quantum dots via a γ-radiation route

Shu-quan Chang*, Bin Kang, Yao-dong Dai, Hong-xu Zhang and Da Chen*

Author Affiliations

College of Material Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing, 210016, People's Republic of China

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Nanoscale Research Letters 2011, 6:591  doi:10.1186/1556-276X-6-591

Published: 14 November 2011


Biocompatible chitosan-coated ZnS quantum dots [CS-ZnS QDs] and chitosan-coated ZnS:Mn2+ quantum dots [CS-ZnS:Mn2+ QDs] were successfully fabricated via a convenient one-step γ-radiation route. The as-obtained QDs were around 5 nm in diameter with excellent water-solubility. These QDs emitting strong visible blue or orange light under UV excitation were successfully used as labels for PANC-1 cells. The cell experiments revealed that CS-ZnS and CS-ZnS:Mn2+ QDs showed low cytotoxicity and good biocompatibility, which offered possibilities for further biomedical applications. Moreover, this convenient synthesis strategy could be extended to fabricate other nanoparticles coated with chitosan.

PACS: 81.07.Ta; 78.67.Hc; 82.35.Np; 87.85.Rs.

quantum dots; γ-radiation; chitosan; ZnS; ZnS:Mn2+; biocompatible