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Gold-silver alloy nanoshells: a new candidate for nanotherapeutics and diagnostics

Dana E Gheorghe1, Lili Cui1, Christof Karmonik2, Audrius Brazdeikis3, Jose M Penaloza1, Joseph K Young4, Rebekah A Drezek45 and Malavosklish Bikram1*

1 Department of Pharmacological & Pharmaceutical Sciences, College of Pharmacy, University of Houston, Texas Medical Center Campus, 1441 Moursund St., Houston, TX 77030, USA

2 The Methodist Hospital, 6565 Fannin, Houston, TX 77030, USA

3 Department of Physics and Texas Center for Superconductivity, University of Houston, 4800 Calhoun Road, Houston, TX 77004, USA

4 Department of Electrical and Computer Engineering, Rice University, 6100 Main Street, MS-366, Houston, TX 77005, USA

5 Department of Bioengineering, Rice University, 6100 Main Street, MS-142, Houston, TX 77005, USA

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Nanoscale Research Letters 2011, 6:554  doi:10.1186/1556-276X-6-554

Published: 13 October 2011

Additional files

Additional file 1:

Figure S1. TEM images of gold-silver alloy (Au:Ag = 5:1) nanoshells deposited on the gold-seeded functionalized Gd:Fe3O4 nanocores. Images A-C indicate dispersed nanoparticles covered with a lighter gold-silver alloy nanoshell. Figure S2. TEM images of gold-silver alloy (Au:Ag = 1:1) nanoshells deposited on the gold-seeded functionalized Gd:Fe3O4 nanocores with an average size diameter of 8.2 ± 0.4 nm (A) and 9.7 ± 0.4 nm (B). Images A and B indicate less dispersed nanoparticles than in the case of using a Au:Ag ratio of 5:1. No gold-silver alloy nanoshells are visible. Figure S3. UV-Vis-NIR spectra of gold-silver alloy nanoshells (Au:Ag = 1:1) deposited on gold-seeded functionalized Gd:Fe3O4 nanocores for 1 (A),7 (B) and 14 days (C) reaction time. Figure S4. Temperature dependence of the ZFC and FC magnetization of the Au-Ag alloy (1:1) nanoshell sample in an external field of 200 Oe.

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