Biofunctionalization of zinc oxide nanowires for DNA sensory applications
- Equal contributors
1 Institute of Solid State Physics, Friedrich-Schiller-Universität, Max-Wien-Platz 1, 07743 Jena, Germany
2 Institute of Photonic Technology (IPHT), PO Box 100239, 07702 Jena, Germany
Nanoscale Research Letters 2011, 6:511 doi:10.1186/1556-276X-6-511Published: 25 August 2011
We report on the biofunctionalization of zinc oxide nanowires for the attachment of DNA target molecules on the nanowire surface. With the organosilane glycidyloxypropyltrimethoxysilane acting as a bifunctional linker, amino-modified capture molecule oligonucleotides have been immobilized on the nanowire surface. The dye-marked DNA molecules were detected via fluorescence microscopy, and our results reveal a successful attachment of DNA capture molecules onto the nanowire surface. The electrical field effect induced by the negatively charged attached DNA molecules should be able to control the electrical properties of the nanowires and gives way to a ZnO nanowire-based biosensing device.