Table 2

Hydrodynamic diameter, polydispersity, zeta potential, and encapsulation efficiency of several drug-loaded liposomes

Drug-loaded liposomes

Hydrodynamic diameter (nm) (mean ± SD)

Polydispersity (mean ± SD)

Zeta potential (mV) (mean ± SD)

Encapsulation efficiency


DPPC/Ch/DSPE-PEG (5:5:1)

115.4 ± 0.5

0.15 ± 0.01

-30 ± 1

97%

1 week after

116 ± 2

0.15 ± 0.01

2 weeks after

116.0 ± 0.8

0.15 ± 0.01

DSPC/Ch/DSPE-PEG (5:5:1)

120 ± 2

0.19 ± 0.01

-27 ± 4

96%

Egg-PC/Ch/DSPE-PEG (5:5:1)

104.3 ± 0.6

0.25 ± 0.01

-19 ± 2

99%

Egg-PC/DCP/Ch (7:2:1)

79.3 ± 0.8

0.37 ± 0.01

-39 ± 3

98%

Egg-PC/Ch/DPPG (6.25:3:0.75)

103.5 ± 0.9

0.12 ± 0.01

-52 ± 6

98%

2 weeks after

95.4 ± 0.5

0.14 ± 0.01

Egg-PC/DPPG/DSPE-PEG (5:5:1)

104 ± 3

0.27 ± 0.01

-43 ± 3

99%


Standard deviations were calculated from the mean of the data of a series of five experiments conducted using the same parameters.

Abreu et al. Nanoscale Research Letters 2011 6:482   doi:10.1186/1556-276X-6-482

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