Figure 2.

Confocal Raman imaging of HepG2 cells before and after exposure to PLGA NPs. (a) Raman spectrum recorded at different positions within a cell from the HepG2 line (ν indicates stretching and δ deformation vibration modes; l denote vibrations of lipids and p of protein). (b) Spot Raman spectra (dark blue) in cells exposed to PLGA NPs covered with PEI, pink and green lines denote the component spectra of PLGA NPs and of the cells. The insets correspond to the image of the cell under study