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Synthesis and characterisation of biologically compatible TiO2 nanoparticles

Richard W Cheyne12, Tim AD Smith2, Laurent Trembleau1 and Abbie C Mclaughlin1*

Author Affiliations

1 The Chemistry Department, University of Aberdeen, AB24 3 UE, UK

2 School of Medical Sciences, University of Aberdeen, AB25 2ZD, UK

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Nanoscale Research Letters 2011, 6:423  doi:10.1186/1556-276X-6-423

Published: 14 June 2011

Abstract

We describe for the first time the synthesis of biocompatible TiO2 nanoparticles containing a functional NH2 group which are easily dispersible in water. The synthesis of water dispersible TiO2 nanoparticles coated with mercaptosuccinic acid is also reported. We show that it is possible to exchange the stearic acid from pre-synthesised fatty acid-coated anatase 5-nm nanoparticles with a range of organic ligands with no change in the size or morphology. With further organic functionalisation, these nanoparticles could be used for medical imaging or to carry cytotoxic radionuclides for radioimmunotherapy where ultrasmall nanoparticles will be essential for rapid renal clearance.