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Open Access Nano Express

Carbon composite micro- and nano-tubes-based electrodes for detection of nucleic acids

Jan Prasek1, Dalibor Huska2, Ondrej Jasek3, Lenka Zajickova3, Libuse Trnkova2, Vojtech Adam2, Rene Kizek2 and Jaromir Hubalek1*

Author Affiliations

1 Department of Microelectronics, Brno University of Technology, Technicka 10, CZ-61600 Brno, Czech Republic

2 Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, CZ-61300 Brno, Czech Republic

3 Department of Physical Electronics, Masaryk University, Kotlarska 2, CZ-61137 Brno, Czech Republic

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Nanoscale Research Letters 2011, 6:385  doi:10.1186/1556-276X-6-385

Published: 16 May 2011

Abstract

The first aim of this study was to fabricate vertically aligned multiwalled carbon nanotubes (MWCNTs). MWCNTs were successfully prepared by using plasma enhanced chemical vapour deposition. Further, three carbon composite electrodes with different content of carbon particles with various shapes and sizes were prepared and tested on measuring of nucleic acids. The dependences of adenine peak height on the concentration of nucleic acid sample were measured. Carbon composite electrode prepared from a mixture of glassy and spherical carbon powder and MWCNTs had the highest sensitivity to nucleic acids. Other interesting result is the fact that we were able to distinguish signals for all bases using this electrode.