Table 4

The AUCa of DTX in mice (n = 4) tissues after i.v. administration of DTX Polysorbate 80 micelles injection and DTX Polysorbate 80/Phospholipid mixed micelles injection.

Tissues

DTX-loaded Polysorbate 80 micelles(μg·h·g-1)

DTX-loaded Polysorbate 80/Phospholipid mixed micelles(μg·h·g-1)

Ratio b


Plasma

10.466

11.407

1.090

Heart

74.263

99.451

1.339

Liver

42.081

71.695

1.704

Spleen

94.203

110.134

1.169

Lung

102.941

103.642

1.007

Ovary and uterus

84.217

104.152

1.237

Kidney

117.103

144.046

1.230


aAUC of the tissues, 0 to 8 h.

bThe ratio was AUCPolysorbate 80/Phospholipid mixed micelles/AUCPolysorbate80 micelles.

Song et al. Nanoscale Research Letters 2011 6:354   doi:10.1186/1556-276X-6-354

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